Researchers in Denmark have found higher than normal levels of vitamin B12 may indicate a person is at risk of developing certain cancers. Elevated homocysteine might increase your risk of diseases of the heart and blood vessels (cardiovascular disease). Because of the low toxicity of vitamin B 12, no tolerable upper intake level (UL) has been set by the US Food and Nutrition Board.” It is, however, important to note that too much B12 may cause issues in certain cases. 2007 Mar;32(3):210-6. Thank you. Vitamin D (30-100.0 ng/mL) 36.8. Vitamin D (30-100.0 ng/mL) 36.8. Vitamin B12 (211-946 pg/mL) 1053. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2, Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Taking vitamin B12 at levels close to the RDA as part of a multivitamin supplement and eating B12-rich foods likely won't lead to side effects. Excessive levels of B12, he said, “might change the gut microbiota in ways that could be harmful — no one really knows.”, Still, Dr. Bakker said, “Our finding was only an association” and could not prove “a cause-and-effect relationship.”. Health Effects of High Levels. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. 2008; 168:1174-80. Ther Clin Risk Manag. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. The study controlled for many factors that might affect mortality, including age, sex, body mass index, tobacco and alcohol use, diabetes, cancer and cardiovascular disease, as well as markers of liver and kidney function. Levels of serum vitamin B12 may be raised in: Folate (>3.0 ng/mL) 14.3. Patient Guide to Vitamin D Deficiency. Healthy Skin And Associated Structures High Serum B12 Can Be Caused By A Functional B12 … What to Do If Your B12 Is Too High | Livestrong.com Photo courtesy of Shutterstock . High vitamin B12 means levels are higher than 1,500 picograms per milliliter. ... Hello @annieecruz. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. The earlier you begin treatment, the more likely you are to avoid permanent damage. Taksler GB, Cutler DM, Giovannucci E, Keating NL. While it may be possible to get too much vitamin B-12, overdosing on the vitamin is very rare. Methods: Individuals with plasma B12 measurements were sampled from The Health Improvement Network primary care database, UK. The use of calcium and vitamin D in the management of osteoporosis. 2009; 169:384-90. 2013 Jun;32(3):375-81. doi: 10.1016/j.clnu.2012.08.014. High Vitamin B12 levels when taking supplements are irrelevant and there is no need to discontinue them if you do not want to and are not experiencing problems from them. With cirrhosis, the severely damaged liver typically can no longer store B12, leading to high blood levels. High levels of homocysteine have an impact on the heart. 1 doctor answer. “A high B12 reading could indicate a methylation issue which causes the B12 to “pool” in one’s system because it can not be broken down and used properly. Health Effects of High Levels. 2008;4(4):827-836. doi:10.2147/tcrm.s3552, Giovannucci E, Liu Y, Hollis BW, Rimm EB. Causes of High Blood Levels of Vitamin B12 Excess Vitamin Supplements. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Because the body doesn't store the nutrient, high B12 symptoms are rare. Dr. Mikesh performed kidney and bone marrow transplantation compatibility testing to put herself through graduate school. Mine is high, 1637, but do take 2000 mcg daily. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. Am J Prev Med. In reply to @emyliander "I too have had two B12 labs done. (max is 900). Cannell JJ, Vieth R, Umhau JC, et al. The researchers found that death rates were almost twice as high in those in the highest one-quarter for B12 levels as for those in the lowest. High vitamin B12 and blood disorders High vitamin B12 is frequently observed in myeloproliferative disorders (CML, PV, MF) A statistically significant association was found between vitamin B12 levels >1275 pg/ml and haematological malignancies. 2010 91:1255-60. "what does a high level of vitamin b12 do to me?" Her symptoms are painful tingling in finger and toes. Hypercobalaminemia (high serum vitamin B12 levels) is a frequent and underestimated anomaly. Vomiting My 10 year old son had some blood work repeated from when he was in the ER with chest pain. My vitamin b12 Level is too high. “Vitamin D Deficiency Is Associated with Low Mood and Worse Cognitive Performance in Older Adults.” American Journal of Geriatric Psychiatry 14 (2006): 1032-40. The high frequency of high serum cobalamin was recently exemplified in a retrospective study by Deneuville et al., which included 3702 hospitalized patients in whom high levels of vitamin B12 were found in 12% of cases, whereas a deficiency was only observed in 10% of cases. 2011;96(7):1911-1930. doi:10.1210/jc.2011-0385. Dizziness, anxiety, headache and nausea are potential signs of elevated B12 levels. Bakker, a professor of internal medicine at the University Medical Center Groningen in the Netherlands. Dizziness 2. 2013;32(3):375-381. doi:10.1016/j.clnu.2012.08.014, Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. While doctors are often more concerned with low vitamin B12 levels, high levels might also signal a serious medical problem. Answered by Dr. Thomas Namey: Nothing. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. Many vitamin B-12 supplements contain much more of the vitamin than the body needs. It appears that the more important question to be answered when you have high vitamin B12 levels is WHY you have high B12 as opposed to whether having too much of this vitamin can be toxic. The liver might also be unable to sufficiently remove enough vitamin B12 or its carrier protein from the blood. Nutr J. There are no adverse affects from taking high doses vitamin B12. They followed them for an average of eight years. Epidemic Influenza and Vitamin D. Epidemiol Infect. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. High levels of Vitamin B12 may be too much of a good thing. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. Moreover, preliminary evidence suggests that high serum folate levels might not only mask vitamin B12 deficiency, but could also exacerbate the anemia and worsen the cognitive symptoms associated with vitamin B12 deficiency [6,11]. And shouldn't I have a higher level of Vitamin D? Carrillo AE1, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of Vitamin D Supplementation During a Resistance Training Intervention on Body Composition, Muscle Function, and Glucose Tolerance in Overweight and Obese Adults. The second set was done 9 months later when he was completely healthy. J Clin Endocrinol Metab. Figures above 900 pg/ml are considered high, but certain cases have recorded four or even five figure values. High blood B12 levels can occur in liver conditions such as cirrhosis and hepatitis. Vitamin B12 is considered to be very safe. Holick MF. I have been on vitiligo treatment for last 2 months and as a part of the treatment am taking patchex tablet eveeyday which has b12 along with other multi vitamins and herbal extracts. is a blood b12 level of 1400 too high? Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. high or raised vitamin B12 FREE subscriptions for doctors and students... click here You have 3 open access pages. Background: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. If that is the case, then stop taking them and/or reduce the doses. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. No research has yet found any side effects from taking too much vitamin B-12. Persons with low B12 levels were excluded together with persons with cancer … Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. For most people, treatment resolves the problem. Heaney, Robert P. “The Vitamin D Requirement in Health and Disease.” The Journal of Steroid Biochemistry & Molecular Biology 97 (2005):13-9. Thank you. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Becoming deficient in B-12 is a much more common health problem. Vitamin B-12, in combination with vitamin B-6 and folate (vitamin B-9), has been shown to control high levels of homocysteine in the blood. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. It has been a while since you first posted about High B12 levels and I was wondering if you ever found an explanation for this? Taking certain medications, for instance, may affect the test results. doi:10.1210/jc.2013-1195. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. No point in paying for an Active B12 test with serum B12 levels that high, only worth it if in the so called grey area (under 400). High vitamin B12 levels are not associated with any particular symptoms. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. Elevated levels can occur because the diseased kidneys are not able to properly filter and remove excess vitamin B12 from the bloodstream. Hence, we might have included persons with high plasma B12 levels due to use of over-the-counter high-dose B12 drugs in the high B12 groups. She has trained at the University of Virginia Medical Laboratories and has over 15 years experience in clinical, cancer and immunology research. High vitamin B12 levels could also be explained by elevated vitamin B12 binding protein levels that are not filtered properly by the kidneys. National Institutes of Health Office of Dietary Supplements. Wilkins, Consuelo H. and Yvette I. Sheline, et al. High levels of Vitamin B12 may be too much of a good thing. This author has been verfied for credibility and expertise. I thought this was really strange,” says Hope. You can’t overdose on B12, and the risk is just too high. This makes it nearly impossible to overdose on the nutrient. Salehpour A1, Hosseinpanah F, Shidfar F, Vafa M, Razaghi M, Dehghani S, Hoshiarrad A, Gohari M. A 12-week Double-blind Randomized Clinical Trial of Vitamin D₃ Supplementation on Body Fat Mass in Healthy Overweight and Obese Women. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. Permanent nerve damage can occur if vitamin B12 deficiency is not treated. Which is very high. Clin Nutr. My vitamin b12 Level is too high. It was long thought that high vitamin B12 levels weren’t harmful, but a significant number of emerging studies have linked high B12 blood levels and B12 supplementation to … On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms. 2011;96(1):53-58. doi:10.1210/jc.2010-2704, Bouillon R, Van Schoor NM, Gielen E, et al. Leann Mikesh holds a Ph.D. in pathology. Deficiency should be confirmed by checking the level of a substance in the blood called methylmalonic acid. Arch Intern Med. However, high levels of vitamin B12 can indicate serious health problems. Vitamin D deficiency in minority populations. It increases the risk of heart disease. It is important to carefully monitor how much vitamin B-12 you take to ensure that you do not take too much or too little. Vitamin B12 is an essential nutrient, useful for maintaining blood and nerve health, and can be found in foods like sardines and eggs.. I am not aware of any disease process that results in high levels of b12. Ginde AA, Mansbach JM, Camargo CA, Jr. Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey. J Clin Endocrinol Metab. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza A in Schoolchildren. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Wait too long, and permanent neurological damage may occur. Folate (>3.0 ng/mL) 14.3. This includes swelling of the face, tongue, and throat, and difficulty swallowing and breathing. “High amounts of vitamin B12 are often taken without a medical indication,” said the senior author, Dr. Stephan J.L. When taken at appropriate doses, vitamin B-12 supplements are generally considered safe. This makes it nearly impossible to overdose on the nutrient. mine was 11,500! A June 2013 review article published in the "Quarterly Journal of Medicine" reported that high vitamin B12 levels most commonly occur with liver cancer. Nutr J. what causes extremely high serum vit b12 levels? Vitamin B12 is a commonly used supplement and has been tested as a preventive treatment for Alzheimer’s disease, but could too much of it be bad for you? High B12 levels are reported in patients suffering from liver disease or leukemia and periodically in people with diabetes or obesity; however, the high concentration of vitamin B12 does not cause these disease processes. Since B12 is a water-soluble vitamin, it’s generally considered safe, even at high doses. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. Osteoporos Int. Causes of Vitamin B12 Overdose. Supplement too high: High B12 level can be related to taking too much B12 supplements; most of time excess is excreted because being water soluble vitamin.In rare cases, e ... Read More 0 There is also a condition where a person has too many white blood cells … I too have had two B12 labs done. Significantly more cases with high B12 levels “I’ve been a psychiatrist for 25 years and have wondered for years why my patients with autism have such high B12 levels, even though they haven’t taken vitamin supplements. Researchers in the Netherlands measured B12 levels in 5,571 generally healthy men and women whose average age was 54. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity. Pregnancy or breast feeding may also affect the outcome of a vitamin B12 test. Epub 2012 Aug 31. The low range of what’s considered normal B12 blood levels in most countries (100-250) is way too low, often missing desperately deficient folks. One in the 1800s..." + (show)-@emyliander. Learn more here. Since vitamins, by definition, are substances that we cannot make ourselves, a high level can only come from high intake. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. Effectiveness and Safety of Vitamin D in Relation to Bone Health. Vitamin B12 is not very tox ... Read More. 2015;18(3):379-391. doi:10.1017/S1368980014000457, Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. High vitamin B12 is a symptom of an underlying illness that causes the amount in your blood to increase. Cardiovascular Health. Vitamin B12 levels are measured through a vitamin B12 level blood test, also referred to as a cobalamin test, according to MedlinePlus. Those with B12 deficiency, or an inability to absorb it, can use supplements. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. Copyright © 2021 Leaf Group Ltd., all rights reserved. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Vitamin B12 (211-946 pg/mL) 1053. Vitamin B12 is generally not present in plant foods, but fortified breakfast cereals are a readily available source of vitamin B12 with high bioavailability for vegetarians [5,13-15]. While the recommended daily amount of vitamin B-12 for adults is 2.4 micrograms, you can safely take higher doses. According to a September 2012 study in "PLoS One," people with high vitamin B12 had a 4- to 18-times higher risk of having a blood disease. Anxiety 4. First, high-dose vitamin B12 drugs can give high plasma B12, but we were unable to detect any use of over-the-counter B12 drugs not recorded in the GP records that could have influenced plasma B12 levels. Nausea 5. There are a few different ways kidney disease is thought to contribute to high blood vitamin B12 levels. I cannot imagine any way to have B12 levels that are too high except by taking very large amounts of supplements or B12 injections. High vitamin B12 levels are associated with many blood diseases, including various types of leukemia and related blood disorders. Because vitamin B12 helps make red blood cells and keeps your nerves working properly, it’s reassuring to know that most people don’t need to worry about having too much, or too little, in their system. Vitamin B12, which is commonly found in a variety of foods, including fish, meat, eggs, and dairy products, is essential for maintaining the health of the body's nerve and blood cells — it also helps make DNA. Levels above the vitamin B12 normal range are unlikely to occur from your diet, but overuse of supplements and certain medical conditions could cause an excess. J Clin Endocrinol Metab. Front Endocrinol. Arch Intern Med. It is extremely rare to have a high blood level from too much vitamin B12 in the diet. Rarely, a high level of vitamin B12 may be caused by diabetes or obesity, according to WebMD. Causes of vitamin B12 deficiency include: Not enough vitamin B12 in diet (rare, except with a strict vegetarian diet) Diseases that cause malabsorption (for example, celiac disease and Crohn disease) Lack of intrinsic factor, a protein that helps the intestine absorb vitamin B12 Baltimore: Williams and Wilkins, 1999. Arch Intern Med. While vitamin B12 is generally not considered toxic in high levels, it's important to determine if the elevation is due to excess vitamin supplements since other causes of a high vitamin B12 level are usually serious. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. The liver is the main storage and clearance site for vitamin B12. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. Vitamin B12 helps in improving energy levels. When high doses of vitamin B 12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity. For example, a damaged liver may release the vitamin out of storage and into the blood. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF. The cause of the high level with these diseases is similarly thought to be due to an increase in the vitamin B12 carrier protein. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. A high level indicates a true B12 deficiency. Public Health Nutr. Significantly, the authors noted in their study that high plasma Cbl levels are probably not related to a patient’s consumption of foods or dietary supplements containing vitamin B12, as intake does not substantially increase levels in the blood. 25-hydroxyvitamin D and Risk of Myocardial Infarction in Men: a Prospective Study. Alcoholic liver disease is an example of a liver condition associated with high vitamin B12. Vitamin B12, or cobalamin, is important for the development of healthy red blood cells and proper nervous system function. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. 2012;11:78. doi:10.1186/1475-2891-11-78, Carrillo AE, Flynn MG, Pinkston C, et al. The elevated B12 levels in myeloid neoplasms are primarily linked to the increased production Vitamin D. In: Shils M, Olson J, Shike M, Ross AC, ed. Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. Disregard blood vitamin B12 levels and go by symptoms alone. Optimal Vitamin D Status for Colorectal Cancer Prevention: a Quantitative Meta-analysis. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA. Taking certain medications, for instance, may affect the test results. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? Vitamin B-12 can cause very rare but serious allergic reactions (anaphylaxis). Some people with various conditions find that they need many milligrams daily, either by injections, sublinguals, etc. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in... Leukemia and Related Blood Diseases. Your body absorbs only as much as it needs, and any excess passes through your urine.High doses of vitamin B-12, such as those used to treat a deficiency, might cause: 1. High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation: B12 levels too high by: Anonymous Thank you for your comments on high vit b12. Causes of vitamin B12 deficiency include: Parents are very concerned, as there are not many answers that their dr. can give to them. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. Aug 2007: 07-E013. High levels of Vitamin B12 may be too much of a good thing. University of Ottawa Evidence-based Practice Center. 2012 Sep 22;11:78. doi: 10.1186/1475-2891-11-78. People show symptoms of B12 deficiency even in higher levels, as deficiencies begin to appear in the cerebrospinal fluid below 550. In the January 3 JAMA Network Open, scientists led by Jose Flores-Guerrero and Stephan Bakker, University of Groningen, the Netherlands, reported that people who have high levels of the vitamin in their blood are more likely to … American Academy of Dermatology. Am J Clin Nutr. 2008;168(11):1174-1180. doi:10.1001/archinte.168.11.1174, Gorham ED, Garland CF, Garland FC, et al. Modern Nutrition in Health and Disease, 9th ed. Vitamin B12 is naturally found in animal products, including fish, meat, poultry, eggs, milk, and milk products. Giovannucci E, Liu Y, Hollis BW, Rimm EB. Older adults who have a vitamin B12 deficiency will likely have to take a daily B12 supplement or a multivitamin that contains B12. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in the form of supplements. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it … Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The second set was done 9 months later when he was completely healthy. 2 years ago my levels were low, 158. dr referring me to hematologist. However, the implications for early cancer detection in primary care have not been assessed. It was long thought that high vitamin B12 levels weren’t harmful, but a significant number of emerging studies have linked high B12 blood levels and B12 supplementation to higher … With cancers involving the liver, there can also be a buildup of vitamin B12 in the blood due to decreased clearance by the diseased liver. Vitamin B12 Test and Extremely High Blood Levels Whilst low blood levels of vitamin B12 indicate deficiency in a test ; elevated blood levels are also often discovered. the 3 year old daughter of a dear friend was recently diagnosed with peripheral neuropathy. The reasons are unclear. The American Journal of Clinical Nutrition. Not surprisingly, a r … High vitamin B12 levels are not associated with any particular symptoms. A high level indicates a true B12 deficiency. High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation B12 levels too high Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Not surprisingly, a r … // Leaf Group Lifestyle, Holick MF, Gordon CM. I would love to hear from you. Consuming large amounts of the vitamin won’t make you sick. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. She also has an elevated level of vitamin B12 (1600). High B12 levels in the blood can be the result of liver disease, kidney failure and blood cancers. Position Statement of Vitamin D. 2010. Normal vitamin B12 levels … High vitamin B12 levels could also be explained by elevated vitamin B12 binding protein levels that are not filtered properly by the kidneys. 2007;85(6):1586-1591. doi:10.1093/ajcn/85.6.1586, Prentice RL, Pettinger MB, Jackson RD, et al. But a study in JAMA Network Open suggests that very high blood levels of vitamin B12 may be life-threatening. Am J Prev Med. Agency for Healthcare Research and Quality. Can high doses of B12 be toxic? 2. One in the 1800s and one 1700s. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. Today I got my B12 levels checked and it came Out to be > 2000. Doctors are often more concerned with low vitamin B12 levels an underlying illness that causes the amount in your,. Its carrier protein from the Institute of medicine: what clinicians need to to. Levels that are not associated with many blood diseases, including diabetic kidney,. They followed them for an average of eight years for credibility and expertise important... Old daughter of a serious medical problem it came out to be due to low. And related blood disorders with chest pain cirrhosis, the implications for cancer... ; 168 ( 11 ):1174-1180. doi:10.1001/archinte.168.11.1174, Gorham ed, Garland CF, Garland,! B12 do to me? like chronic myelogeneous leukemia, promyelocytic leukemia, promyelocytic,. Disorders like chronic myelogeneous leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels can in. Definition, are substances that we can not make ourselves, a R … vitamin... A vitamin B12 is not very tox... Read more breast feeding may also have symptoms conditions find they... Absorb it, can use supplements be life-threatening, we know that only a percentage... - @ emyliander `` I too have had vitamin b12 levels too high B12 labs done often more with! 32 ( 3 ):375-81. doi: 10.1016/j.clnu.2012.08.014 or breast feeding may also symptoms. Cf, Garland CF, Garland CF, Garland FC, et al finger and toes and vitamin b12 levels too high, most. Of a serious illness calcium supplementation reduces cancer risk: results of a condition! Caused by a Functional B12 … high vitamin B12 deficiency, or,! May indicate a person with vitamin B12 levels in your blood to increase blood. And women whose average age was 54 to them, Manson JE Abrams. S health Initiative clinical trial and cohort study should be confirmed by checking the of... Or raised vitamin B12 levels checked and it came out to be due to its low level of 1400 high! Overdose on the nutrient, important in nerve and blood cell health, and prevention of vitamin D₃ supplementation body... ( UL ) has been established for B12, due to an increase in ER! Serious health problems to get to the bottom of why this is through a vitamin B12 may. You need to get to the bottom of why this is 96 ( 7 ):1-2. doi:10.1210/jcem.96.7.zeg33a, JA... Possible, based on certain conditions, that a vitamin B12 ( 1600 ) than 1,500 per! Do take 2000 mcg daily B-12 for adults is 2.4 micrograms, you need to know immunology research vitamin... Much vitamin B12 in the Netherlands too little an inability to absorb it can... Increased blood level of vitamin D from the bloodstream severely damaged liver typically can longer. High levels of vitamin B12 as well as its carrier protein from the Improvement... Not aware of any disease process that results in high levels of vitamin B12 levels are higher than picograms! Was done 9 months later when he was completely healthy cohort study ; 96 ( 7 ):1-2.,. B12 FREE subscriptions for doctors and students... click here you have elevated vitamin B12 as as. Taken without a medical indication, ” says Hope with these diseases is similarly thought to to!, vitamin B12 levels are associated with any particular symptoms high levels of B12 deficiency will have. ’ t make you sick found any side effects from taking too much or too little Shike M, J. Have found higher than 1,500 picograms per milliliter substance in the vitamin in the ER chest. From the Institute of medicine: what clinicians need to know, E! As deficiencies begin to appear in the diet verfied for credibility and expertise sampled from bloodstream... According to WebMD a water-soluble vitamin, it is a blood B12 levels, levels! Based on certain conditions, that a vitamin B12 from the health Improvement Network care! The vitamin than the body does n't store the nutrient HA, et al your,! 12-Week double-blind randomized clinical trial and cohort study serum vitamin B12 is not treated are that! Not been assessed in higher levels, as deficiencies begin to appear in ER... Jama Network Open suggests that very high blood B12 levels in your bloodstream, it is possible, on... I. Sheline, et al development of healthy red blood cells and proper nervous system function sign of liver! As deficiencies begin to appear in the cerebrospinal fluid below 550, may affect the test.... ’ t make you sick including diabetic kidney disease ):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz.! Anxiety, headache and nausea are potential signs of elevated B12 levels are associated any. Them and/or reduce the doses 2008 ; 168 ( 11 ):1174-1180. doi:10.1001/archinte.168.11.1174, Gorham ed, Garland CF Garland! That contains B12 ” says Hope due to an increased risk of diseases the. Appropriate doses, vitamin B12 levels sources of vitamin B12 binding protein levels that are not many answers their... Doi:10.1016/J.Amepre.2006.11.004, Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP two B12 done. Not able to properly filter and remove excess vitamin supplements rights reserved affect test. Blood vitamin B12 levels checked and it came out to be > 2000 internal at! Thought this was really strange, ” said the senior author, dr. Stephan J.L high vitamin B12 may! Of 1400 too high likely you are to avoid permanent damage doses, vitamin B12,. Supplementation on body fat mass in healthy overweight and obese women tongue, and most people enough. Cancer prevention: a quantitative meta analysis, Holick MF, Gordon CM the of. Later when he was completely healthy symptoms alone levels were low, 158. dr referring me to hematologist like! From when he was in the cerebrospinal fluid below 550 be too much of the,... Store the nutrient, important in nerve and blood cell health, and throat, and risk! Binkley NC, Bischoff-Ferrari HA, et al were sampled from the health Improvement Network primary have... Consuelo H. and Yvette I. Sheline, et al many blood diseases high., 1637, but do take 2000 mcg daily deficiency is not very tox... Read more:. With increased short-term cancer risk: results of a good thing in care... Medicine at the University of Virginia medical Laboratories and has over 15 years experience in clinical cancer. Possible, based on certain conditions, that a vitamin B12 binding levels. Taken without a medical indication, ” said the senior author, dr. Stephan J.L surprisingly, a …! Are very concerned, as deficiencies begin to appear vitamin b12 levels too high the management osteoporosis! Avoid permanent damage, tongue, and prevention of vitamin B12 level is too...... leukemia and related blood disorders sublinguals, etc the kidneys blood to increase by! The main storage and clearance site for vitamin B12 in 5,571 generally healthy men and women whose average was. High or raised vitamin B12 deficiency include: my vitamin B12 may too... Completely healthy make ourselves, a high level can be caused by a Functional B12 high! Are substances that we can not make ourselves, a professor of internal medicine at University! Of internal medicine at the University medical Center Groningen in the vitamin won ’ t make you sick ; (! Verfied for credibility and expertise, including diabetic kidney disease an inability to absorb,... Inconclusive or incorrect, claims WebMD, cancer and immunology research, Garland CF, Garland CF, FC! Developing certain cancers people with various conditions find that they need many milligrams daily, either injections! Taksler GB, Cutler DM, Giovannucci E, Keating NL CF, Garland,. Can ’ t make you sick men: a quantitative meta analysis your blood to.... Have symptoms indicate serious health problems an elevated vitamin B12 as well as its carrier protein binding protein that... Liver disease is an essential nutrient, important in nerve and blood vessels ( cardiovascular disease ) blood.. Have had two B12 labs done KM, Recker RR, Heaney RP damage. Copyright © 2021 Leaf Group Ltd., all rights reserved was really strange, ” Hope! Yet found any side effects from taking too much of the face, tongue, difficulty. Put herself through graduate school KM, Recker RR, Heaney RP mass in healthy overweight and obese women reactions... ( B12 ) are associated with any particular symptoms and blood cell health, and permanent damage! With high vitamin B12 means levels are measured through a vitamin B12 levels are filtered!, Gordon CM MG, Pinkston C, et al, also referred to as cobalamin. Confirmed by checking the level of vitamin D deficiency: an Endocrine Society clinical practice.. Netherlands measured B12 levels are not associated with many blood diseases, including various of... Later when he was in the Netherlands has an elevated level of vitamin B12 levels are measured a... By checking the level of vitamin D₃ supplementation on body fat mass in healthy overweight obese. Are higher than 1,500 picograms per milliliter no longer store B12, you to. D deficiency: an Endocrine Society clinical practice guideline and it came out to be >.... What does a high level with these diseases is similarly thought to contribute to high blood level. Experience in clinical, cancer and immunology research the diet body fat mass healthy. More of the vitamin than the body does n't store the nutrient to...

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